Acupuncture Research Today is a free monthly online journal that collates and summarizes the latest research about Acupuncture, including details on alternative medicine, uses, benefits, treatment, chinese medicine.

Acupuncture inhibits kainic Acid-induced hippocampal cell death in mice.

Kim ST, Jeon S, Park HJ, Hong MS, Jeong WB, Kim JH, Kim Y, Lee HJ, Park HJ, Chung JH

Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul 130-701, Republic of Korea. acufind@khu.ac.kr.

We examined whether acupuncture can reduce both the incidence of seizures and hippocampal cell death using a mouse model of kainic acid (KA)-induced epilepsy. ICR mice were given acupuncture once a day at acupoint HT8 (sobu) bilaterally during 2 days before KA injection. After an intracerebroventricular injection of 0.1 microg of KA, acupuncture treatment was subsequently administered once more (total 3 times), and the degree of seizure was observed for 20 min. Three hours after injection, the survival of neuronal cells and the expressions of c-Fos, c-Jun, and glutamate decarboxylase (GAD)-67 in the CA1 and CA3 were determined using immunohistochemistry and Western blotting techniques. Acupuncture reduced the severity of the KA-induced epileptic seizure and the rate of neural cell death, and it also decreased the expressions of c-Fos and c-Jun induced by KA in the hippocampus. Furthermore, acupuncture increased GAD-67 expressions in the same areas. These results demonstrated that it could inhibit the KA-induced epileptic seizure and hippocampal cell death by increasing GAD-67 expressions.

Published 22 February 2008 in J Physiol Sci, 58(1): 31-8.
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